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Test Code LAB4942 CNS Demyelinating Disease Eval, Serum

Performing Laboratory

St. Louis Children's Hospital Sendout to Mayo Medical Laboratories

Specimen Requirements

Specimen Type: Blood

Patient Preparation: for optimal antibody detection, it is recommended to collect specimen before the initiation of immunosuppressant medication.

Container/Tube     

Preferred:  Gold/Red SST Vacutainer®.

Acceptable: Plain, red-top Vacutainer®.
Collection Volume: 6.0 mL (minimum 4.0 mL)

Special Instructions: Include relevant clinical information, name, phone number, and e-mail address (if applicable) of ordering physician.

Sample Rejection

Specimens that are grossly hemolyzed and/or grossly lipemic.
Mislabeled or unlabeled specimens.

Logistics

Test Availability:  Daily

Cut-off time: None

Days set up by performing lab: Monday, Tuesday, & Thursday

Turnaround Time: 8-10 days

Reference Values

Reference Interval: 

MOG FACS, S: Negative

NMO/AQP4 FACS, S: Negative

Reference values apply to all ages

Critical Value: None established

Methodology

Flow Cytometry

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Limitations

AQP4-IgG antibodies and myelin oligodendrocyte glycoprotein (MOG)-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).

Additional Information

FOR SLCH CORE LABORATORY USE ONLY

Lab Processing Instructions: Centrifuge to separate. If specimen is collected in a plain, red-top tube aliquot sample into a 5-mL screw-cap plastic vial for transport.

Transport Temperature: Refrigerated
Analyte Stability: 

Ambient (unprocessed): NA
PROCESSED
Ambient: 72 hours

Refrigerated: 28 days

Note: Include relevant clinical information, name, phone number and e-mail address of ordering physician if provided.
Reject specimen if grossly hemolyzed and/or grossly lipemic

Test Classification and CPT Code

CNS demyelinating disease evaluation  (EPIC Test# LAB4942)

86053
86363

86053-titer (if appropriate)
86363-titer (if appropriate)

LOINC

102085-5

Last Reviewed

08/2025